Last updated: 2018-09-10
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| Version | Author | Date |
|---|---|---|
| c24d8ce | bingrus | 2018-09-10 |
| Target.s. | Mechanism.of.action | Class | group | |
|---|---|---|---|---|
| 17-AAG | HSP90 | Heat Shock Protein 90 (hsp90) Inhibitor | Other targeted therapies | 1 |
| AZD0530 | Src, Abl/Bcr-Abl, EGFR | Src and Abl inhibitor | Kinase inhibitor | 1 |
| Erlotinib | EGFR | EGFR Inhibitor | Kinase inhibitor | 1 |
| Lapatinib | EGFR, HER2 | EGFR and HER2 Inhibitor | Kinase inhibitor | 1 |
| ZD-6474 | Abl, EGFR, Flt3, C-KIT, RET, VEGFR-1, KDR, FLT4 | Multi-kinase inhibitor | Kinase inhibitor | 1 |
| AEW541 | IGF-1R | IGF-1R Inhibitor | Kinase inhibitor | 2 |
| L-685458 | Gamma Secretase | gamma-Secretase Inhibitor | Other targeted therapies | 2 |
| Paclitaxel | beta-tubulin | Microtubule-Stabilizing Agents | Cytotoxic | 2 |
| Panobinostat | HDAC | Histone Deacetylase (HDAC) Inhibitor | Other targeted therapies | 2 |
| Sorafenib | Flt3, C-KIT, PDGFRbeta, RET, Raf kinase B, Raf kinase C, VEGFR-1, KDR, FLT4 | Multi-kinase inhibitor | Kinase inhibitor | 2 |
| TAE684 | ALK | ALK Inhibitor | Kinase inhibitor | 2 |
| AZD6244 | MEK | MEK1 and MEK2 Inhibitor | Kinase inhibitor | 3 |
| PD-0325901 | MEK | MEK1 and MEK2 Inhibitor | Kinase inhibitor | 3 |
| PLX4720 | RAF | Raf kinase B Inhibitor | Kinase inhibitor | 3 |
| Irinotecan | Topoisomerase I | NA | NA | 4 |
| Nutlin-3 | MDM2 | MDM2 Inhibitor | Other targeted therapies | 4 |
| PF2341066 | c-MET, ALK | c-MET and ALK Inhibitor | Kinase inhibitor | 4 |
| RAF265 | Raf kinase B, KDR | Raf kinase B and KDR Inhibitor | Kinase inhibitor | 4 |
| TKI258 | EGFR, FGFR1, PDGFRbeta, VEGFR-1, KDR | Multi-kinase inhibitor | Kinase inhibitor | 4 |
| Topotecan | Topoisomerase I | DNA Topoisomerase I Inhibitor | Cytotoxic | 4 |
| LBW242 | IAP | Inhibitor of Apoptosis Proteins (IAP) Inhibitor | Other targeted therapies | 5 |
| Nilotinib | Abl/Bcr-Abl | Abl Inhibitor | Kinase inhibitor | 5 |
| PD-0332991 | CDK4/6 | CDK4/6 Inhibitor | Kinase inhibitor | 5 |
| PHA-665752 | c-MET | c-MET Inhibitor | Kinase inhibitor | 5 |
R version 3.5.0 (2018-04-23)
Platform: x86_64-apple-darwin15.6.0 (64-bit)
Running under: macOS High Sierra 10.13.4
Matrix products: default
BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
locale:
[1] en_AU.UTF-8/en_AU.UTF-8/en_AU.UTF-8/C/en_AU.UTF-8/en_AU.UTF-8
attached base packages:
[1] stats4 parallel stats graphics grDevices utils datasets
[8] methods base
other attached packages:
[1] kableExtra_0.9.0 knitr_1.20 GSEABase_1.42.0
[4] graph_1.58.0 annotate_1.58.0 XML_3.98-1.16
[7] AnnotationDbi_1.42.1 IRanges_2.14.11 S4Vectors_0.18.3
[10] GSVA_1.28.0 heatmaply_0.15.2 viridis_0.5.1
[13] viridisLite_0.3.0 plotly_4.8.0 ggplot2_3.0.0
[16] dplyr_0.7.6 gplots_3.0.1 GEOquery_2.48.0
[19] Biobase_2.40.0 BiocGenerics_0.26.0 reshape_0.8.7
loaded via a namespace (and not attached):
[1] colorspace_1.3-2 class_7.3-14 modeltools_0.2-22
[4] mclust_5.4.1 rprojroot_1.3-2 rstudioapi_0.7
[7] flexmix_2.3-14 bit64_0.9-7 mvtnorm_1.0-8
[10] xml2_1.2.0 codetools_0.2-15 R.methodsS3_1.7.1
[13] robustbase_0.93-2 geneplotter_1.58.0 shinythemes_1.1.1
[16] jsonlite_1.5 workflowr_1.1.1 cluster_2.0.7-1
[19] kernlab_0.9-27 R.oo_1.22.0 shiny_1.1.0
[22] readr_1.1.1 compiler_3.5.0 httr_1.3.1
[25] backports_1.1.2 assertthat_0.2.0 lazyeval_0.2.1
[28] limma_3.36.3 later_0.7.3 htmltools_0.3.6
[31] tools_3.5.0 bindrcpp_0.2.2 gtable_0.2.0
[34] glue_1.3.0 reshape2_1.4.3 Rcpp_0.12.18
[37] trimcluster_0.1-2.1 gdata_2.18.0 crosstalk_1.0.0
[40] iterators_1.0.10 fpc_2.1-11.1 stringr_1.3.1
[43] rvest_0.3.2 mime_0.5 gtools_3.8.1
[46] dendextend_1.8.0 DEoptimR_1.0-8 MASS_7.3-50
[49] scales_1.0.0 TSP_1.1-6 hms_0.4.2
[52] promises_1.0.1 RColorBrewer_1.1-2 yaml_2.2.0
[55] memoise_1.1.0 gridExtra_2.3 stringi_1.2.4
[58] RSQLite_2.1.1 highr_0.7 gclus_1.3.1
[61] foreach_1.4.4 seriation_1.2-3 caTools_1.17.1.1
[64] rlang_0.2.2 pkgconfig_2.0.2 prabclus_2.2-6
[67] bitops_1.0-6 evaluate_0.11 lattice_0.20-35
[70] purrr_0.2.5 bindr_0.1.1 labeling_0.3
[73] htmlwidgets_1.2 bit_1.1-14 tidyselect_0.2.4
[76] plyr_1.8.4 magrittr_1.5 R6_2.2.2
[79] DBI_1.0.0 pillar_1.3.0 whisker_0.3-2
[82] withr_2.1.2 RCurl_1.95-4.11 nnet_7.3-12
[85] tibble_1.4.2 crayon_1.3.4 KernSmooth_2.23-15
[88] rmarkdown_1.10 grid_3.5.0 data.table_1.11.4
[91] blob_1.1.1 git2r_0.23.0 digest_0.6.16
[94] diptest_0.75-7 webshot_0.5.0 xtable_1.8-3
[97] tidyr_0.8.1 httpuv_1.4.5 R.utils_2.7.0
[100] munsell_0.5.0 registry_0.5
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